Declan Lynch found this bad news today.
There is a known bug in Google Chrome 48 that is affecting DOJO resource loading which in turn is causing XPages application to stop working.
End users may see the page freeze and interaction with things like pagers stop working. From a development point of view having the DevTools running and the Disable Cache option enabled means you may not see this issue during development.
PLEASE go to that issue and sign in with a Google account and star it. Hopefully the more stars the higher priority it’ll get. Comments might also be helpful.